abstract：:Mutations in the p53 tumour suppressor gene are found at high frequency in bladder cancer. There is strong evidence that p53 plays an important role in controlling the cell cycle after DNA damage by ionizing radiation. However, the effect of loss of p53 function on radiosensitivity is not yet clear. Radiotherapy combi...

journal_title：International journal of radiation biology

authors： Ribeiro JC,Barnetson AR,Fisher RJ,Mameghan H,Russell PJ

更新日期：1997-07-01 00:00:00

abstract：:The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...

journal_title：International journal of radiation biology

authors： O'Reilly JP,Mothersill C

更新日期：1997-07-01 00:00:00

abstract：:Tikvah Alper's interest in science was broad, from scrapie to mammalian cells and cancer. Much of her own work focused on cell lethality, like that of many other radiobiologists, but this was natural because of the simplicity of the endpoint cell survival and its relevance to cancer therapy. Tikvah had broader interes...

journal_title：International journal of radiation biology

authors： Elkind MM

更新日期：1997-06-01 00:00:00

abstract：:One of the major goals of cancer research is to identify and understand the causes of cellular proliferation. The role of cell death, or lack thereof, in carcinogenesis, tumour growth, metastatic spread and response to treatment has been largely overlooked even though the morphology of apoptosis (programmed cell death...

journal_title：International journal of radiation biology

authors： Blank KR,Rudoltz MS,Kao GD,Muschel RJ,McKenna WG

更新日期：1997-05-01 00:00:00

abstract：:The effect of gamma-radiation on aqueous solutions of saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG), 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine (lysoPC), and bovine brain sphingomyelin (SM) has been investigated. It is shown that th...

journal_title：International journal of radiation biology

authors： Edimecheva IP,Kisel MA,Shadyro OI,Vlasov AP,Yurkova IL

更新日期：1997-05-01 00:00:00

abstract：:We have previously described a cell-free assay that can be employed to study rejoining of radiation-induced DNA double-stranded breaks (dsb) in 'naked' DNA prepared from agarose-embedded cells using an extract of HeLa cells as a source of enzymes. Rejoining of dsb in this assay is absolutely dependent on cell extract ...

journal_title：International journal of radiation biology

authors： Cheong N,Iliakis G

更新日期：1997-04-01 00:00:00

abstract：:A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...

journal_title：International journal of radiation biology

authors： Groch KM,Khan MA,Brooks AL,Saffer JD

更新日期：1997-03-01 00:00:00

abstract：:Radiation survival curves have been obtained for crypts in the small and large intestine of male BDF1 mice using the microcolony assay. Four regions of the small intestine and three regions of the large intestine were studied. One of the major objectives was to determine the optimal conditions for the microcolony assa...

journal_title：International journal of radiation biology

authors： Cai WB,Roberts SA,Bowley E,Hendry JH,Potten CS

更新日期：1997-02-01 00:00:00

abstract：:We used three common fluorescent probes to measure pericentric inversion frequencies in 2.9 Gy 60Co gamma-irradiated human lymphocytes. For a given chromosome, the first probe is specific to one telomeric region, the second probe is specific to one subcentromeric region and the third probe is specific to the centromer...

journal_title：International journal of radiation biology

authors： Lucas JN,Hill FS,Chen AM,Burk CE

更新日期：1997-01-01 00:00:00

abstract：:The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupt...

journal_title：International journal of radiation biology

authors： Tzaphlidou M,Kounadi E,Leontiou I,Matthopoulos DP,Glaros D

更新日期：1997-01-01 00:00:00

abstract：:An assay system was developed to detect changes of restriction fragment profiles obtained after pulsed-field gel electrophoresis (PFGE) for DNA from mammalian cells that were irradiated and incubated for repair. DNA was prepared from irradiated log-phase human melanoma cells (MRI 221) after incubation for repair (6 h)...

journal_title：International journal of radiation biology

authors： Latz D,Dewey WC,Flentje M,Lohr F,Wenz F,Weber KJ

更新日期：1996-12-01 00:00:00

abstract：:We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

journal_title：International journal of radiation biology

authors： Wouters BG,Sy AM,Skarsgard LD

更新日期：1996-12-01 00:00:00

abstract：:I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

journal_title：International journal of radiation biology

authors： Hutchinson F

更新日期：1996-11-01 00:00:00

abstract：:Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT s...

journal_title：International journal of radiation biology

authors： Wood PJ,Scobie M,Threadgill MD

更新日期：1996-11-01 00:00:00

abstract：:In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

journal_title：International journal of radiation biology

authors： Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

更新日期：1996-10-01 00:00:00

abstract：:During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...

journal_title：International journal of radiation biology

authors： Liu FF,Lee C,Li JH

更新日期：1996-10-01 00:00:00

abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

journal_title：International journal of radiation biology

authors： Burnet NG,Wurm R,Peacock JH

更新日期：1996-09-01 00:00:00

abstract：:Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

journal_title：International journal of radiation biology

authors： Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

更新日期：1996-08-01 00:00:00

abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

journal_title：International journal of radiation biology

authors： Volf V,Burgada R,Raymond KN,Durbin PW

更新日期：1996-07-01 00:00:00

abstract：:The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

journal_title：International journal of radiation biology

authors： Little MP,Muirhead CR

更新日期：1996-07-01 00:00:00

abstract：:Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...

journal_title：International journal of radiation biology

authors： Mateos S,Gordon AT,Steel GG,McMillan TJ

更新日期：1996-06-01 00:00:00

abstract：:Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...

journal_title：International journal of radiation biology

authors： Raaphorst GP,Wang G,Stewart D,Ng CE

更新日期：1996-05-01 00:00:00

abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...

journal_title：International journal of radiation biology

authors： Li W,Zheng R,Su B,Jia Z,Li H,Jiang Y,Yao S,Lin N

更新日期：1996-04-01 00:00:00

abstract：:Terminally differentiated cells usually do not divide and are, thus, reproductively dead. To elucidate the significance of radiation-enhanced differentiation to reproductive cell death, murine erythroid progenitor cells were gamma-irradiated in plasma clot cultures and the development of haemoglobinized clones was stu...

journal_title：International journal of radiation biology

authors： Schwenke K,Peterson HP,von Wangenheim KH,Feinendegen LE

更新日期：1996-03-01 00:00:00

abstract：:Existing models of chromosome aberrations produced by ionizing-radiation predict equal numbers of dicentrics and translocations if the dose is so low that complex aberrations can be ignored. We show that, for a specific subset of aberrations detected by FISH, dicentric/translocation equality is predicted even at highe...

journal_title：International journal of radiation biology

authors： Lucas JN,Chen AM,Sachs RK

更新日期：1996-02-01 00:00:00

abstract：:We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radio...

journal_title：International journal of radiation biology

authors： Alsbeih MG,Fertil B,Arlett CF,Malaise EP

更新日期：1996-02-01 00:00:00

abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

journal_title：International journal of radiation biology

authors： Kondo T,Riesz P

更新日期：1996-01-01 00:00:00

abstract：:Induction by gamma-radiation, UV radiation or hydroxyurea of RecA gene product synthesis in Escherichia coli, monitored as beta-D-galactosidase in recA-lacZ fusion strains, was shown to be inhibited if 2-mercaptoethylamine (MEA) was added before treatment with the inducing agents. If cysteine (Cys) at low concentratio...

journal_title：International journal of radiation biology

authors： Naslund M,Anderstam B,Granath F,Ehrenberg L

更新日期：1996-01-01 00:00:00

abstract：:Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There ...

journal_title：International journal of radiation biology

authors： Allen JE,Henshaw DL,Keitch PA,Fews AP,Eatough JP

更新日期：1995-12-01 00:00:00

abstract：:The studies of the late effects of atomic-bomb (A-bomb) radiation on the immune system were started about 20 years after the bombings in 1945. The most remarkable late effects of radiation are the functional and quantitative abnormalities of T and B cells in survivors exposed to high doses (> or = 1.0 Gy). Abnormaliti...

journal_title：International journal of radiation biology

authors： Akiyama M

更新日期：1995-11-01 00:00:00

abstract：:Intact Chinese hamster ovary cells were exposed to the restriction endonucleases (REs) AluI or BamHI. In metaphase spreads from these cells, 300 breakpoints per RE were localized in G-banded chromosome type aberrations (dicentrics, translocations, rings, terminal and interstitial deletions). The majority of breakpoint...

journal_title：International journal of radiation biology

authors： Folle GA,Obe G

更新日期：1995-10-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta 1) plays a central role in wound healing, so its perturbation by radiation may contribute to the acute and late effects seen in irradiated skin. TGF beta 1 mRNA expression was measured by PCR, in the skin of the CD1 and CBA mouse, exposed to Sr-90 beta from an 11-mm diameter s...

journal_title：International journal of radiation biology

authors： Randall K,Coggle JE

更新日期：1995-09-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsbs) were measured in CHO-K1 cells by means of an experimental approach involving constant-field gel electrophoresis and densitometric scanning of ethidium bromide stained gels. For X-irradiation, an induction efficiency of 36 +/- 5 dsbs (Gy x cell)-1 was determined. With t...

journal_title：International journal of radiation biology

authors： Heilmann J,Taucher-Scholz G,Kraft G

更新日期：1995-08-01 00:00:00

abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

journal_title：International journal of radiation biology

authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

更新日期：1995-07-01 00:00:00

abstract：:Sister chromatid exchanges (SCEs) were analysed in lymphocytes from 12 control persons and 33 Chernobyl clean-up workers. The group of Chernobyl clean-up workers consisted of civilians who were forced to go to Chernobyl to clean up environmental contamination caused by Chernobyl disaster. On average, they received 0.1...

journal_title：International journal of radiation biology

authors： Lazutka JR,Dedonyte V

更新日期：1995-06-01 00:00:00

abstract：:To characterize further the radiosensitivity of severe combined immunodeficiency (scid) mice, the induction of micronuclei (MN) in polychromatic erythrocytes as well as cell killing and translocation induction in stem cell spermatogonia was studied. Scid mice turned out to be clearly hypersensitive for X-ray-induced c...

journal_title：International journal of radiation biology

authors： Van Buul PP,De Rooij DG,Zandman IM,Grigorova M,Van Duyn-Goedhart A

更新日期：1995-05-01 00:00:00

abstract：:Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

journal_title：International journal of radiation biology

authors： Goud SN

更新日期：1995-04-01 00:00:00

abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....

journal_title：International journal of radiation biology

authors： Abend M,Rhein A,Gilbertz KP,Blakely WF,Van Beuningen D

更新日期：1995-03-01 00:00:00

abstract：:Solid human tumours contain areas with low oxygen tension (pO2). For bioreductive drugs it is important to define the cytotoxic effect according to drug concentration and to clinically relevant pO2. In this study, the pO2 dependence of the survival of three human cell lines (HRT 18, Na11 +, and MEWO), exposed to tirap...

journal_title：International journal of radiation biology

authors： Lartigau E,Guichard M

更新日期：1995-02-01 00:00:00

abstract：:Eelpout (Zoarces viviparus), a marine fish, were exposed to gamma-radiation at a dose-rate of 2.0 mGy h-1. They were injected with the antigen trinitrophenyl-keyhole limpet haemocyanin (TNP-KLH) and their specific humoral immune response to the TNP hapten measured. There were no differences in the primary antibody res...

journal_title：International journal of radiation biology

authors： Greenwood LN,Knowles JF

更新日期：1995-01-01 00:00:00